Breadcrumb
A comprehensive patient-specific prediction model for temporomandibular joint osteoarthritis progression
Schematic representation for the steps of the TMJ OA prognosis prediction model鈥檚 development. (A) Clinical, imaging, and biological data were collected from the study subjects, at baseline, and utilized to create the OA Prognosis Prediction model.聽
(B) Clinical and imaging data were collected, at follow-up visits, to label the training dataset with the changes of the participants鈥� health status following 2 to 3 y of conservative management.
What is it?
Temporomandibular joint osteoarthritis (TMJ OA) is a common condition causing jaw pain and difficulty moving the jaw.
What problem does it aim to solve?
The study aimed to improve prediction of how TMJ OA progresses and how patients respond to treatment.
How does it work?
Researchers followed 106 patients, with 74 of them getting checked after 2 to 3 years of non-surgical treatment. This study identified a comprehensive set of clinical, quantitative imaging, and biological biomarkers for precise prediction of TMJ OA disease progression. Researchers developed an open-source tool based on a robust method called Ensemble via Hierarchical Predictions through Nested cross-validation (EHPN), which surpassed the performance of the 48 models tested. The EHPN model achieved an F1 score of 0.82, indicating strong performance and reliability with new, unseen data, and minimizing false positives and negatives.
What are the real-world implications?
The use of the EHPN model may revolutionize the standards of care, providing clinicians with an accurate tool for anticipating the future status of TMJ OA patients, thereby enhancing their decision-making process.
What are the next steps?
Further refinement of the model.
Source
, Proceedings of the National Academy of Sciences USA聽2024聽 Vol. 121聽 No. 8聽聽
Authors
Najla聽Al Turkestani
Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
罢别苍驳蹿别颈听尝颈
Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
闯辞苍补蝉听叠颈补苍肠丑颈
Department of Orthodontics, 91成人导航, Arthur A. Dugoni School of Dentistry, San Francisco, CA 94103
惭补谤肠别濒补听骋耻谤驳别濒
Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
闯耻补苍听笔谤颈别迟辞
Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
贬颈苍补听厂丑补丑
Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
贰谤颈办补听叠别苍补惫颈诲别蝉
Department of Periodontics & Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
贵补产颈补苍补听厂辞办颈
Department of Periodontics & Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
驰耻箩颈听惭颈蝉丑颈苍补
Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
惭补谤驳丑别谤颈迟补听贵辞苍迟补苍补
Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
础谤惫颈苍诲听搁补辞
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109
Department of Computational Medicine & Bioinformatics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
贬辞苍驳迟耻听窜丑耻
Department of Radiology and Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
尝耻肠颈补听颁别惫颈诲补苍别蝉
Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI 48109
